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Description
P53 directly increases GH production, endocrine GH promotes the expression of ATM through JAK2-activated TRIM29, and next regulates HR pathway to repair DNA damage (Sho et al., 2011)

Cardiac and metabolic safety-related mechanisms Several studies have identified molecular mechanisms underlying potential safety liabilities

creatinine clearance

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Tadenev ALD, Burgess RW

doi: 10.1111/ene.13861
