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To reduce propionate synthesis, two main approaches have been reported: (1) Antibiotics: These are used to inhibit gut microbiota, thereby reducing microbial production of propionate, and (2) Carnitine supplementation: Propionyl-CoA can be converted to propionylcarnitine by carnitine acetyltransferase or to propionate by propionyl-CoA hydrolase, both of which help regulate cellular propionyl-CoA levels

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