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As a glutaminase inhibitor, CB-839 is highly sensitive to esophageal squamous cell carcinoma (ESCC), which is highly dependent on glutamine metabolism for energy, providing a new possibility for the treatment of ESCC [69]

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The most commonly reported side effects were mild and included headache, minor gastrointestinal disturbances (flatulence, mild diarrhea at high doses), upper respiratory symptoms, and mild injection site reactions