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Hepatocyte growth factor decreases nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) activation to downregulate adhesion molecules such as ICAM-1/E-selectin on the endothelial cell surface (Makondo et al., 2004
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[10] Due to the potential for harmful drug interactions and other serious adverse effects, oral ketoconazole should only be used to treat serious fungal infections when no other antifungal therapies are available

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