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Elevated cytokines like IL-6 and TNF- activate microglia and astrocytes, causing damage to critical brain areas such as the hippocampus and DLPFC, which are essential for memory and cognition

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It is possible that the increased ROS was buffered, in part by ALDH, however there was no functional assessment of oxphos levels in this study to understand the source of the ROS (Hsueh et al., 2021)