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In contrast, at hKOR, mitragynine and 7-hydroxymitragynine acted as competitive antagonists with IC 50 values of 8.5 and 7.9 M, and pA2 values of 1.4 and 0.49 M respectively, when compared to the reference agonist U-50488

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FOXO transcription factors, particularly FOXO4, play a crucial role in regulating cellular mechanisms associated with longevity and tissue protection against damage

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