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In 1993, da-Silva (228) showed that BAC peaked later and that the mean area under the BAC-time curve (AUC), an indicator of systemic availability of the drug, was significantly smaller in lactating women when compared to a control group

This is called the analgesic ceiling

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Yes, when administered under licensed supervision

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Coran AG, Drongowski RA 1987 Studies on the toxicity and efficacy of a new amino acid solution in pediatric parenteral nutrition
