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Relevant gene polymorphisms with different racial distributions are identified sources of variability in drug responses by the modulation of drug-metabolizing cytochrome P450 enzymes discussed in this report

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Nrf2 activation leads to the upregulation of detoxifying enzymes that neutralize reactive aldehydes like 4-HNE, thereby reducing their inhibitory effects on pathways such as PI3K/AKT/mTOR and Wnt/-catenin [134]

doi: 10.3390/md10081784

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