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Recent studies have highlighted METH-induced alterations in the hippocampus, such as reduced STX17 expression, impaired autophagosome maturation, and cognitive decline ( 2.3 Manifestations of nervous system injury METH abuse induces neurological damage that manifests as cognitive impairment, psychiatric symptoms, and motor dysfunction, with clear distinctions between the acute and chronic phases of use

While generally well-tolerated in research settings, comprehensive human safety data is lacking

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[DOI] [PubMed] [Google Scholar] Tarozzo G, Bortolazzi S, Crochemore C, Chen SC, Lira AS, Abrams JS, Beltramo M