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Reduced GSH levels shown by decreases in this ratioboth in the plasma and intracellularlyreflect intracellular shifts in oxidative burden and are indicative of immune dysfunction and progression of various disease states such as infection, sepsis, and age-related immune system decline (Morris et al., 2012

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To appreciate this fact one can look to research done on calorie-restriction diets

Nutritional Supplementation with Chlorella pyrenoidosa Lowers Serum Methylmalonic Acid in Vegans and Vegetarians with a Suspected Vitamin B Deficiency

This gap in monitoring was also identified as an area for action by the James Lind Alliance in 2020, supporting the need for regular testing due to the increased risk of gastric cancer

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