glutathione-responsive prodrug Preparation and Characterization of a Doxorubicin Modified by 2-Nitrobenzenesulfonamide Group—Its Selective Cytotoxicity Toward Cells with Enhanced Glutathione Production Construction of glutathione-responsive paclitaxel prodrug

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Origins & Discovery The tripeptide glycyl-L-histidyl-L-lysine (GHK) was isolated from human plasma in 1973 when Pickart observed that young serum caused old liver tissue to produce proteins more characteristic of younger individuals. Its high affinity for Cu rapidly forms the chelate now known as GHK-Cu, which occurs naturally in plasma, saliva, and urine

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