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Funding This work was supported by the Projects of Medicine and Health Science Technology Development Program in Shandong Province [2016WS0499], Shandong Provincial Natural Science Foundation of China Grants [ZR2019PH025]

Significant immune dysregulation has also been found in individuals with late-onset anxiety disorder, suggesting the presence of a specific late-onset anxiety subtype with a distinct etiology that could benefit from more personalized treatment strategies (Vogelzangs et al., 2013)

The beneficial effects (endogenous and exogenous) of the agent supposed to mimic the activity of the supposed mediator (i.e., prostaglandins, corticosteroids) should link theory and practice

doi: 10.1016/s0167-4781(00)00238-4

WalkerLESillsGJJorgensenAAlapirttiTPeltolaJBrodieMJet al

Nevertheless, after intervention with GHK-Cu, a significant reduction in these pathological changes was observed (Figures 2DG)