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Senomorphics: A class of therapeutics that reduce the toxicity of senescent cells by dampening their secretome (e.g., SASP)

To prepare non-reduced samples, -mercaptoethanol was omitted from loading buffer and samples were loaded without boiling

Ludwig T, Eggenschwiler J, Fisher P, D'Ercole AJ, Davenport ML, Efstratiadis A

However, dysregulation of the NLRP3 inflammasome results in pathological inflammation [35]

doi: 10.1038/cdd.2011.111 90 LuJPengYZouJWangJLuSFuTet al