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This protection occurs when theres intense inflammatory stress

Johns Hopkins APL is expected to complete work under the initial award in November 2026.

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Besides, a TME-responsive targeted nanoparticle co-delivering the gene expressing interleukin-12 and the colony-stimulating factor-1 receptor inhibitor PLX3397 can efficiently inhibit tumor growth and metastasis by stimulating the proliferation and activation of T lymphocytes, repolarizing TAMs, reducing MDSCs, promoting DCs maturation, and promoting the secretion of anti-tumor cytokines (217)