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Keywords: chondrocyte, senescence, autologous chondrocyte implantation, senolytic, FOXO4-DRI Introduction Autologous chondrocyte implantation (ACI) is a biomedical treatment that repairs cartilage injury in the knee joint, which has been shown to reduce pain and facilitate mobility recovery (Kreuz et al., 2019)

At certain concentrations and time points, overstimulation may suppress rather than enhance melatonin output, highlighting the importance of dose, timing, and context when considering clinical protocols [1]

PDE4B controls 1AR but not 2AR responses in cardiac myocytes, suggesting a localized function to control 1AR-dependent excitationcontraction coupling (Mika et al., 2014)

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doi: 10.1016/j.redox.2023.102987 26 XuJHanXXiaNZhaoQChengZ