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Animals tests for acute skin irritation assessment usually follow the Draize rabbit test while other accepted assays for skin sensitization include Local Lymph Node Assay (LLNA) and Guinea Pig Maximisation Test (GPMT)

"Efficacy of high-intensity laser therapy in the treatment of chronic neck pain: a randomized double-blind placebo-control trial." Lasers in Medical Science , 32(3):687-694
Deficiency of B vitamins in women of childbearing age, pregnant, and lactating women in Brazil: a systematic review

As a result, you may feel numbness in the feet or hands

Functional Recovery: In rat models, it preserved retinal structure and increased electroretinogram (ERG) amplitude by ~75%