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Tirzepatide produced 47% greater weight loss than semaglutide at maximum doses over the study period

[DOI] [PubMed] [Google Scholar] 87.Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG, Lieber MM, Cespedes RD, Atkins JN, Lippman SM, Carlin SM, Ryan A, Szczepanek CM, Crowley JJ, Coltman CA., Jr The influence of finasteride on the development of prostate cancer

Cagrilintide, like native amylin and pramlintide, does not cross the bloodbrain barrier in large amounts

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Bottom line on the preclinical class: it shows measurable effects in rodents over days of dosing-plus-training, the best of it is one clean independent study, and it tells you nothing reliable about if or when a human would notice anything