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Autophagosomes arise from a single membrane structure known as the phagophore, which elongates and then closes in on itself, sequestering cytoplasmic material in the process

One explanation is the elevation of AMPK, which is an upstream factor of PGC-1 regulation [27,28]

However, existing research and clinical experience suggest that comprehensive preventive measures, monitoring, treatment adjustments, and multidisciplinary collaboration are crucial in managing cardiotoxicity induced by EGFR-TKIs
Analysing the data of the four samples by Circos plots revealed variant density across 14 chromosomes with more variants towards the telomeric ends (Fig

1996;270(2):C673C678
