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This is why research suggests that an optimal combination of the three vitamins, B1, B6 and B12, is more effective at relieving nerve damage symptoms and restoring nerve function than taking a single vitamin supplement

Using this serum vitamin B 12 cut-off alone, the prevalence of vitamin B 12 deficiency is estimated to be in the range of 5% to 15%.3 4 5 6 However, when higher serum vitamin B 12 cut-off at 258 pmol/L (350 pg/mL) or using elevated serum homocysteine or MMA level in addition to a low or low-to-normal serum vitamin B 12 level to diagnose vitamin B 12 deficiency, the prevalence of deficiency increases to 40.5%.1 3 Also, the prevalence of vitamin B 12 deficiency appears to increase with age among the elderly population.4 5 Furthermore, reports have indicated that institutionalised elderly with multiple co-morbidities and with increasing dependency are more prone to vitamin B 12 deficiency than non-institutionalised (free-living) elderly

Most people have 23 pairs of chromosomes (46 total)

Some experts have estimated that 1-3% of the population has histamine intolerance, with a higher prevalence in middle-aged females

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GPs cannot rely on symptoms or macrocytosis to determine which patient needs testing for B12 deficiency, nor can these clinical parameters be used for follow-up when results are low or borderline