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N Engl J Med 2013;368:238594

First, Zhang and colleagues evaluated whether human MDR cancer cells possessed the cell-state plasticity for entering DTP state during canonical MDR-reversal treatment using a combination of chemotherapeutic agents and MDR1 inhibitor verapamil

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Unlike its established role in CD95-mediated apoptosis of nucleated cells, ceramide promotes eryptosis primarily by enhancing Ca 2+ sensitivity rather than directly facilitating Ca 2+ entry ( 2+ , eryptosis is fine-tuned by a cohort of kinases that interface with multiple signaling nodes illustrated in Figure 2

aegypti it was previously observed high levels of glucose 6-phosphate dehydrogenase (G6PDH) activity at the very beginning of Aedes aegypti embryogenesis, which nevertheless decreased up to 5 HAE, indicating its significant involvement in the initial stages of embryonic development, prior to the retraction of the germ band (Vital et al., 2010)

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