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82 In addition, LNPs can be loaded with both lipophilic and water-soluble therapeutic drugs due to their hydrophilic and phobic properties, where the hydrophilic drugs can be loaded inside, and the lipophilic drugs can be encapsulated in phospholipid bilayers or adsorbed on the surface of liposomes, 83 moreover, such LNPs loaded with therapeutic drugs can increase drug concentrations in tumor cells, reduce therapeutic dose and toxicity, and treatment resistance compared to free drugs

Archived (PDF) from the original on 19 December 2020

73 , e264e266 (2021)

Drugs 77:20372048

We summarize how intracellular lipolysis affects lipid-mediated signalling, metabolic regulation and energy homeostasis in multiple organs

doi: 10.1016/j.neulet.2006.09.070