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[2] Ghorbani Y, Schwenger KJP, Allard JP

Moreover, SLE patients with renal involvement exhibited significantly higher serum KYN levels and KYN/TRP ratios than those without renal damage, suggesting that activation of the kynurenine pathway may exacerbate glomerular mesangial cell injury via pro-oxidative mechanisms [51] (Fig

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Systemic absorption from creams is low but because high oral vitamin A is a known teratogen and topical safety data are limited, most clinicians recommend stopping retinoids when pregnant or trying to conceive