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The activation of the Nrf2 pathway triggers a massive endogenous production of Phase II detoxification enzymes, including Heme Oxygenase-1 (HO-1) and NAD(P)H quinone oxidoreductase 1 (NQO1)

As a result, controlling oxidative stress has become a key neuroprotective strategy

[DOI] [PMC free article] [PubMed] [Google Scholar] 5.Grka P., Kowalski Z.M., Zabielski R., Guilloteau P

78 McGuire S, Bostad E, Smith L, Witten M, Siegel FL, Kornguth S

Stay away from saunas, hot tubs, and prolonged sun exposure for at least 24 hours, as heat can increase swelling or bruising

doi:10.1016/j.freeradbiomed.2008.05.004
