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Overview [edit] Several copper(II)-peptide complexes occur naturally

So that was a huge issue

120 Table 9 compares the characteristics of the primary studies included in the systematic reviews against the inclusion criteria of our review

Merabet N, Bellien J, Glevarec E, Nicol L, Lucas D, Remy-Jouet I, Bounoure F, Dreano Y, Wecker D, Thuillez C, Mulder P (2012) Soluble epoxide hydrolase inhibition improves myocardial perfusion and function in experimental heart failure

Proc Natl Acad Sci U S A 114:E3563E3572

Because the Jackson Laboratory strain of C57BL/6 J, which lacks the Nnt gene was used in the NZB-129 heteroplasmy studies, it is possible that mitochondrial ROS production caused by the NZB tRNA Arg 9821 insA allele was enhanced on this strain background resulting in enhanced selection against PGCs or primary or mature oocytes with significant levels of the NZB mtDNA and increased ROS production