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The authors hereby assign to the journal the copyright in the above identified article to be transferred, including supplemental tables, illustrations or other information submitted in all forms and media throughout the world, in all languages and formats, effective when and if the article is accepted for publication

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Once activated, TGF- binds to its receptor complex, initiating phosphorylation of Smad2 and Smad3, which then form a complex with Smad4 and translocate to the nucleus and regulate gene transcription (70)

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