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Epub 2011 Mar 31

These beneficial microbes may stimulate the production of intratumoral ROS, activating intrinsic apoptotic pathways and reducing tumor cell survival

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The glycoprotein mutant with elaborated LPS structures, 579, induced consistently increased CXCL-8 secretion from gastric cells compared to wildtype bacteria ( Figure 3B ), whereas the LPS mutant wzk led to consistently decreased CXCL-8 secretion ( Figure 3C )

Since their original definition as DAMPs in 2003, the list of endogenous molecules are increased considerably (4) and now includes high-mobility group box 1 protein (HMGB-1), heat shock proteins (HSPs), histone and extracellular matrix components (for example, hyaluronic acid and biglycan)

L., Eliasson, P., Magnusson, S