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Additionally, cocaine use in PLWH upregulates expression of activated leukocyte cell adhesion molecule in brain endothelium, promoting monocyte adhesion and transmigration across the BBB (131)
This is what may lead to cognitive conditions like dementia

Motor neurons reach from the brain to the spinal cord and from the spinal cord to the muscles throughout the body

Surprisingly, memantine acting on the K ATP channel of SNc DA neurons provides clinical benefits for the treatment of PD [180]

2026 Jun 15;14(6):1344

They achieve this by reducing the levels of MDA and reactive oxygen intermediates and increasing the activities of SOD and GPX (Arat et al., 2010
