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In OTLFK, the kyphotic deformity alters the normal sagittal alignment of the spine, leading to abnormal biomechanical forces on the intervertebral discs

Tesamorelin stimulates pituitary GH release via the GHRH receptor while ipamorelin stimulates the same cells via the GHS-R1a (ghrelin) receptor

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NNMT is an enzyme that methylates nicotinamide (vitamin B3) using S-adenosylmethionine (SAM) as a methyl donor

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