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Studies show maximum ALT improvement typically occurs around 30 weeks of treatment

& Ferwerda, G

Liu, Y., Chi, S., Cao, Y

The primary antibodies utilized in this study included DNA/RNA Damage (1:200 dilution, ab62623, Abcam, America), p-ATM (1:50 dilution, R380751, ZEN-BIOSCIENCE, China), p-ERK (1:50 dilution, R380698, ZEN-BIOSCIENCE, China), 8-oxoguanine (1:50 dilution, 130914, Santa Cruz Biotechnology, America), H2A.X (phospho S139) antibody (1:200 dilution, ab81299, Abcam, America), Paxillin antibody (1:200 dilution, ab32084, Abcam, America), The cytoskeleton was stained with FITC-conjugated phalloidin (1:200 dilution, A12379, Invitrogen, America)

Consistent with this phenotype, we found that aged DJ1 KO hMIDOs contained significantly increased levels of monomeric phosphorylated -syn at day 200 relative to isogenic control midbrain organoids (Fig

it provides the energy to break chemical bonds