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Do not use direct heat (such as hot water, a heating pad, or a heat lamp) to warm the person

NLRP3 inflammasome activation requires two signals: the initiation of NLRP3 gene transcription through the NF-B pathway and the activation of NLRP3 inflammasome sensors [67]

doi: 10.1038/onc.2008.17 162 DaiYGrantS

Protocols recommend an initial loading phase of 22.5 mg twice weekly for 46 weeks, followed by a maintenance dose of 22.5 mg every 12 weeks