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The causes of LOAD are still unknown, but several factors have been shown to modify the risk of developing LOAD, such as environmental, lifestyle, ethnic, socioeconomic, and genetic factors

In summary, the rationale of employing DMF in psoriasis consists in reducing cellular inflammation both by decreasing glutathione intracellular levels and by inducing a switch in immune response toward an anti-inflammatory/immunoregulatory setting (68, 69)

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