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Conclusion In conclusion, this review provides a comprehensive summary of recent molecular research shedding light on the complex mechanisms through which HIV-1-related factorssuch as viral proteins and RNAsmediate microglial activation, leading to neuroinflammation and the development of NeuroHIV

doi: 10.1073/pnas.0605374104 14 BagiA.RiiserE

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Consequently, their dysfunction has been implicated in different neurological disorders (Lu and Nasrallah, 2018), and despite it is supposed to be selective for NMDARs, it cannot be really considered a highly selective drug, as it can also bind to other receptors and ion channels (Kotermanski and Johnson, 2009)

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