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This substitution prevented the interaction that occurs in wild-type (WT) A42 of the peptide carbonyl oxygen of Ile31 with the S-atom of Met35, which, as noted above, were shown to be within a van der Waals distance of each other (121)

Thymosin Alpha-1, for example, has a plasma half-life of approximately 2 hours but exerts immunomodulatory effects for considerably longer periods, likely because of downstream signaling cascades that persist well beyond peptide clearance

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doi: 10.3892/etm.2015.2964, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 74.Ringseis R, Keller J, Eder K