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We summarize key mechanisms of action, categorize clinically relevant peptide classes, and address current limitations, including gaps in human data, safety considerations, and regulatory ambiguity

Agents that can inhibit or reverse this metabolic switch can be pivotal in the advancement of cancer therapeutics with reduced side effects and improved efficacy

The type of linker is not merely a matter of chemical synthesis design

In phase 2 trials, 1-2% of retatrutide participants experienced biliary disorders, including cholecystitis (1 participant) and cholelithiasis (2 participants)