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Higher absolute bioavailability for hydroxychalcone may be due to its higher tissue binding, high molecular weight, higher water solubility, and higher volume of distribution

In summary, after long-term administration of GLPs, by maintaining glucose and lipid metabolism homeostasis, exerting antioxidative, inflammation-reducing, anti-fibrotic impacts, and regulating gastrointestinal-heart axis, the physiological state and pathological findings in rats remained normal, with no obvious organ damage observed, indicating good safety

Impairments in GSH-associated pathways suggest reduced cellular defence and are therefore considered as markers of increased oxidative stress [15, 17]

Selected publications were full-text screened independently by 3 researchers (A.K., D.G., K.G.) to assess the suitability to eligibility criteria

An increase in biological activity can be therapeutically positive (e.g

A simple and effective strategy for labeling cysteine sulfenic acid in proteins by utilization of [small beta]-ketoesters as cleavable probes