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Description
Semaglutide: This is a GLP-1 receptor agonist that helps to control blood sugar levels, reduce appetite, and increase feelings of fullness
It binds GHRH receptors on the pituitary gland, prompting the glands own pulsatile release of growth hormone (GH) , which in turn raises circulating IGF-1 [2]

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However, new therapies are under investigation, for example, mitapivat, a small-molecule allosteric activator of PK has shown to induce a clinically relevant hemoglobin increase and improvement in hemolytic parameters in a phase II clinical trial (Grace et al., 2019b)

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While modulation of the GSH-antioxidant system has provided promising preclinical results, some of these compounds demonstrate unacceptable toxicity profiles (eg, buthionine sulfoximine)
