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Inhibition of GSH and Trx metabolism with buthionine sulfoximine (BSO) and auranofin (AUR), respectively, induced significant decreases in clonogenic survival compared to either drug alone in FaDu, Cal-27 and SCC-25 HNSCC cells in vitro and in vivo in Cal-27 xenografts

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At times, small peptides undergo degradation during protein production and hence using suitable tags could circumvent the problem

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

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Over the last 25 years, more than a dozen drugs representing five drug classes have been developed and approved for the treatment of this devastating disease