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The Intergroup Melanoma Surgical Trial compared radial excision margins of 2 cm versus 4 cm in patients with melanomas of 1 mm to 4 mm in thickness.[5][Level of evidence A1] With a median follow-up of 10 years, there was no significant difference in OS, disease-specific survival, or local recurrence between the two treatment groups

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Cell Mol Neurobiol 20:7795 Morisco A, Accardo A, Tesauro D, Palumbo R, Benedetti E, Morelli G (2011) Peptide-labeled supramolecular aggregates as selective doxorubicin carriers for delivery to tumor cells