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In four RCTs, ALC was found to be more effective than placebo (PBO) in individuals with depression

Eur J Phys Rehab Med 55(1):7988

A.et al (2017)

Selenium supplementation in the management of thyroid autoimmunity during pregnancy: results of the SERENA study, a randomized, double-blind, placebo-controlled trial

Gut microbes consume acylcarnitines in a category-specific pattern, suggesting that the metabolic requirements and utilization efficiency of these compounds vary among bacterial species [231]

In case of some people having specific dietary restriction, supplementation might be an option to fulfill the bodys requirement
