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unsupervised training programs on balance and muscle strength in older adults: a systematic review and meta-analysis

6.4 Oxidative stress Oxidative stress plays a critical role in hypertension due to the fundamental roles of ROS and redox signaling in molecular, cellular, and systemic processes that contribute to endothelial injury, vascular dysfunction, cardiovascular remodeling, renal impairment, sympathetic nervous system excitation, immune cell activation, and systemic inflammationkey factors in the pathophysiology of hypertension [240, 241]

In summary, this study demonstrated an improvement in pain with a vitamin supplementation regime inclusive of B12 but did not show improved efficacy with addition of folate [31]

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