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Metabolic intermediates including -ketoglutarate and acetyl-CoA fulfill biosynthetic demands for nucleotide/lipid production while enabling epigenetic reprogramming via TET (Ten-eleven translocation enzymes) dioxygenase-mediated DNA demethylation (108, 109)

Metabolic recoding of epigenetics in cancer

10.2174/156720106777731118 From NLM

Diversity between the systems appears to have evolved through use of novel proteins, and matching of protein components between translocation machineries 8