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Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation

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It has been established that Ang II stimulates mitochondrial ROS (mtROS) formation and opening of the mitochondrial permeability transition pore (mPTP) with resultant leakage of the generated mtROS to the cytosol [162, 163]
