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doi: 10.3389/fnbeh.2016.00121, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] Franco R., Rivas-Santisteban R., Navarro G., Pinna A., Reye I

In human astrocytes, S1PR1 activation by siponimod improved Ca 2+ signaling and receptor internalization (162), while it inhibited NFB by nuclear translocation of Nrf2, a regulator of antioxidant response (64)

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( c ) Body weight time course, ( d ) changes in body weight, fat mass, and fat free mass from day 5 to 26

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