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Research suggests BPC-157 may modulate NO production in a way that supports tissue repair rather than exacerbating inflammation

Furthermore, acetylcholine-induced production of bioavailable nitric oxide was lower in aortic rings from GPx1 / ApoE mice than ApoE / mice, and the double knockout mice had increased 3-nitrotyrosine staining in atheromatous plaques, similar to earlier findings of endothelial dysfunction in GPx1-deficient mice [39, 70, 71]

Also review whether other factors might be causing breakouts

BPC-157 detection BPC-157 has a remarkably short half-life of less than 30 minutes

The targeted interventions paid off, resulting in fewer symptoms and more confidence in his longterm gut health

Cadenas E, Davies KJ