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As HTX is rapidly metabolized after ingestion, its conjugated metabolites are the ones mainly detected [50,56,70,71]
For instance, during periods of increased stress or illness, the demand for glutathione rises, underscoring its importance in immune response

Yu LJ, Zhang KJ, Zhu JZ, Zheng Q, Bao XY, Thapa S, et al
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1b), indicating the colony formation process occurred only in escapers (i.e., due to the 6-fold decrease in pyruvate dehydrogenase activity (Supplementary Fig

Biomaterials 32 , 42834292 (2011)

This, and other similar studies prompted an early hypothesis that there may be an optimal amount of intracellular calcium, and over or under stimulation of highly calcium permeable NMDARs leads to cellular death (Choi 1995