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It particularly and consistently interacts with the NO-system, in various models and different species (4, 8, 25-27)

doi: 10.3945/an.116.012716 146

Selenium toxicity is accompanied by hair and nail loss, as well as nausea, diarrhea, skin rashes, fatigue, irritability and nervous system issues

A randomized, double-blind, placebo-controlled, clinical trial to evaluate the benefits of Nigella sativa seeds oil in reducing cardiovascular risks in hypertensive patients

found that leukocytes may induce sperm DNA damage with cascade amplification effects, while affected patients have significantly increased ROS production rates and reduced sperm motility