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In mouse embryonic fibroblasts, the elevation of CHAC1 protein expression following As III exposure is negatively regulated by the Tribbles homolog 3 (TRIB3), which limits CHAC1s pro-death potential ( 6 A methylation

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In addition, reactive astrocytes at the perimeter of the fibrotic scar proliferate to form perilesional barrier that protects the adjacent viable nervous tissue

However, these effects are associated with the intake of vitamin C exceeding 1 g over several weeks [22,23]

*Correspondence: Mingzhi Shen [email protected] Wu [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Science and Environmental Communication, a section of the journal Frontiers in Cardiovascular Medicine Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers