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In aged animal models, growth hormone secretion is typically reduced by 50-70% compared to young adult levels, contributing to many of the physiological changes associated with aging including alterations in muscle mass, increased adiposity, reduced bone density, modified immune parameters, and decreased tissue repair capacity

Absorbance at 450 nm was then measured using a microplate reader, with lower absorbance indicating reduced viability

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Advantages: Dual route: injectable for deep joints, topical for superficial joints