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[DOI] [PubMed] [Google Scholar] 144.Shrestha B., Tang L., Hood R.L
White spots on teeth, many appearing on front teeth, can occur for a variety of reasons

Interestingly, it has been described that VDR expression can be modulated by vitamin D itself (40), thus demonstrating an involvement of both ligand and receptor downmodulation in AD
Also, check that they dont contain benzyl alcohol, or at least verify that youre not sensitive to it
Front Pharmacol 5:151 Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J (1992) S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds

According to the NewcastleOttawa Scale (NOS) for case-control studies (n = 2) (Yamane et al., 1995