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8 shRNA validation of Cre-dependent recombination

Mathiesen, D

C) Keine Hemmung der in die endogene Glutathion-Biosynthese eingeschalteten Enzyme (gamma-Glutamylcystein-Synthetase, das Regulationsenzym durch Glutathion im Sinne eines negativen feed-back

From the International Pediatric Sepsis Conference 2005 to the Sepsis-3 Consensus

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This assessment is even more relevant if it is considered that the oxidized state would lead to an intramolecular disulfide bond, which usually could not lead to a single reduced Cys residue under reducing conditions, but must allow two bonds with mPEG-MAL, unless the second Cys residue is structurally or spatially hidden